Management of tumour lysis syndrome in children: what is the evidence for prophylactic rasburicase in non-hyperleucocytic leukaemia?
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چکیده
منابع مشابه
The Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملthe efficacy of single dose rasburicase in prevention or treatment of tumor lysis syndrome in children
background: tumor lysis syndrome (tls) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. the role of rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of tls has been demonstrated in recent years. we aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
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Tumour lysis syndrome is a catastrophic complicalion of treatment of certain neoplasms. It is usually seen with the tumours that have high growth fractions, increased bulk and extreme sensitivity to cytotoxic therapy. Most commonly it occurs in association with hematologic malignancies such as lymphomas and leukaemias. Rarely it has been observed with solid tumours like small cell lung cancer, ...
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Economic implications of rasburicase treatment in adult patients with tumour lysis syndrome.
BACKGROUND Rasburicase is a recombinant urate-oxidase enzyme used to reduce high levels of plasma uric acid (PUA) resulting from tumour lysis syndrome (TLS). Rasburicase reduces PUA levels within 4 hours of administration, thereby minimizing the risk of serious complications from TLS. Treatment pattern analyses indicate rasburicase is often used in combination with allopurinol; however, no stud...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2011
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2010.08506.x